Over the last two to three decades, there has been a 15-25 % increase in many countries in the number of women giving birth to large infant. Fetal macrosomia is associated with an increased risk of complications both for the mother and the newborn. In current obstetrics, the macrosomic fetus represents a frequent clinical challenge. The early detection and identifi cation of the risks associated with fetal macrosomia is important to managing the pregnancies and at last the timing and mode of delivery. This article provides possibilities of ultrasound diagnosis throughout the pregnancy and investigates the effectiveness of fetal measurements in identifying the large fetus (Tab. 1, Ref. 24). Text in PDF www.elis.sk.

Short oral presentation abstracts prenatal clinic setting. Maternal levels of PAPP-A were measured at the time of the first prenatal visit (9 to 13+6 weeks) as part of the combined ultrasound and biochemical screening study. Low PAPP-A was defined as the lowest 5% of values for gestational age (< 0.4 MoM) and high AFP was defined as the top 5% of values for gestational age (> 1.9 MoM). Intrauterine growth restriction was defined as birth-weight ≤ 3 th centile according to our local customized charts. The risk of IUGR in women with a low PAPP-A and normal AFP was compared with a control group with low PAPP-A and high AFP. No results were reported to either the obstetrician or patient. Results: A total of 5617 pregnant women were attended for prenatal care in our institution between January 2010 and December 2011. Of the 301 patients with a PAPP-A < 0.4 MoM, 141 had a determination of AFP done between 15 and 18 weeks and perinatal outcome is known for 96 of these patients. Women with a low PAPP-A were not more likely to have elevated levels of AFP. Only 4 patients (4.2%) had a low PAPP-A and high AFP. We had 6 cases of IUGR (6%): 3 cases (3.2%) in the group of low PAPP-A and normal AFP and 3 cases (75%) in the group of low PAPP-A and high AFP. The odds ratio for delivering a baby with IUGR for women with low PAPP-A and high AFP was 89 (95% confidence interval [CI] 7-1127). Conclusions: Although the small numbers of the study, this preliminary data suggest that low maternal levels of PAPP-A between 8 and 13+6 weeks and high levels of AFP between 15 and 18 weeks are highly associated with IUGR. OP31.02Single nucleotide polymorphism in pre-eclampsia prediction Objectives: Sonography predicts pre-eclampsia (PE) due to Doppler flowmetry in early pregnancy in some cases (1). On the other hand, evaluation of single nucleotide polymorphism (SNP) may put women at risk of developing PE in advance before starting the pregnancy (2). Many observations have revealed that a decreased level of HLA-G in the maternal serum correlates with pregnancy disorders, such as recurrent spontaneous abortion and PE (3). Methods: Using PCR we analyzed DNA samples from 15 PE women admitted to our department from 9/2010 to 2/2012 and 88 healthy women as out-patients. We evaluated the heterozygous and homozygous HLA-G genotype +14/−14, −14/−14 and +14/+14 in PE patients and in a control group (Fig. 1a). Results: In relation to 14 bp polymorphism screening, we determined frequencies of three HLA-G genotypes: the heterozygous genotype +14/−14 was revealed in 40% of PE patients versus 51.14% of a control group, the homozygous genotype −14/−14 was found in 20% of PE patients versus 28.41% of a control group and the homozygous genotype +14/+14 was found in 40% of PE and in 20.45% of a control group. Calculating the p-value revealed the highest statistical differences of homozygous genotype +14/+14 frequencies between pre-eclamptic women and a control group (P = 0.1094) (Fig.1b.). Conclusions: Our preliminary results have shown the association of 14 ...