Group housing of calves can pose a challenge in identifying respiratory disease; therefore, it is necessary to develop tools that can identify these disease events. In this experiment, pre-weaned calves (n = 30) were housed in groups with an automatic calf feeder and were fitted with an accelerometer. Step activity, lying behaviors, and feeding behaviors were recorded to determine the effect of respiratory disease. All calves were health scored twice daily, and calves with respiratory scores ≥5 were diagnosed with respiratory disease (n = 10). Each diseased calf was match paired with a healthy control based on the date of disease diagnosis, breed, and age. Control calves were determined to be healthy if they had respiratory scores ≤4, as well as fecal, navel, and joint scores of 0 or 1. Diseased calves were less active before, on the day of, and after respiratory disease diagnosis. Furthermore, diseased calves had reduced lying frequencies starting 2 d before diagnosis, as well as after diagnosis. Last, diseased calves consumed less milk on the day of diagnosis when compared with healthy controls. Step activity, lying bouts, and milk intake may prove to be a useful tool in identifying respiratory disease under practical farming, but this requires further research.