While space system functioning, faults are unacceptable. The price of any early failure in the operation of a spacecraft is much higher than the cost of the development and manufacture of the failed element. Modern verification methods do not provide the required reliability. For the mechanisms of spacecraft, a methodology of design and technology reliability analysis has been developed, which allows one to achieve reliability, which is not available for modern verification methods. The article provides the purpose of the new analysis, the basic foundations and a brief description of the analysis methodology. The technique was tested in the development of space-based mechanisms and hydraulic automation for oil equipment that operate without human intervention once during the service life. The basic approaches to the implementation of the design and technology reliability analysis make it possible to develop many branches (fork version) to solve problems of ensuring the quality and reliability of products for various purposes, increasing the efficiency of development and professional skill of designers.