No abstract

Purpose: to study the effect of the thickness and vascular density of the retina on its photosensitivity in diabetic macular edema. Material and methods. 9 patients (13 eyes) aged from 26 to 79 years (average age 62.1 ± 16 years) with a diagnosis of diabetic retinopathy (DR), diabetic macular edema (DME) were examined. In addition to the standard ophthalmological examination, a complex of specialized research methods was performed, including microperimetry, optical coherence tomography (OCT) and OCT with angiography (OCT-angio) of the posterior segment of the eye. At the same time, the influence of morphometric parameters on functional changes in the retina in the corresponding segments with a diameter of 6 mm was analyzed. Results. The study was a high inverse correlation relationship in the majority of cases between the parameters of the relevant sectors according microperimetry and OCT and OCT-angio in central zone of diameter 1, 3 and 6 mm and a direct correlation between central retinal thickness by OCT diagnosis and the so-called parameter K, denoting the number of points with sensitivity below 24 dB according microperimetry with a high degree of confidence (p<0.01, p<0.05). Conclusion. According to the results of our study, a direct correlation was found between the vascular density of the superficial and deep capillary plexuses and the parameters of photosensitivity in patients with DME. At the same time, the relationship between the thickness and light sensitivity of the retina is inverse. Key words: diabetic retinopathy, diabetic macular edema, optical coherence tomography, microperimetry, angiography.

Macular hole (MH) is one of the most common pathologies of the macular area of the retina which leads to a significant decrease in visual acuity. The article presents early comparative morphofunctional results of surgical treatment of 60 patients (22 men and 38 women) with MH of the III–IV stages according to Gass and the minimum diameter (MinD) MH 404–696 microns. All patients included in the study had pseudophakia and have not previously undergone endovitreal interventions. Patients with MH with a diameter of 404–696 μm were randomized and divided into 3 equal groups: after three-port 25G pars plana posterior vitrectomy the patients of the first group underwent peeling of the inner limited membrane (ILM) with the convergence of the edges of MH and vitreous cavity tamponade with 16 % gas-air mixture of perfluoropropane (C2F6). In the area of the macular defect, patients of the second group underwent application of autologous conditioned plasma (ACP) in the PFСs environment and the convergence of the edges of MH. In patients of the third group, MH was closed using the technique of an inverted ILM flap. In patients of groups 2 and 3 the operation was completed by tamponade of the vitreous cavity with sterile air. Standard and special research methods, such as optical coherence tomography of the macular zone, were performed before surgery, 5 days and 1 month after surgery in all patients from groups 2 and 3. Patients from group 1 were examined before surgery and 1 month after surgical treatment, due to the long-lasting gas-air mixture in the vitreous cavity. Restoration of the correct structure of the fovea with the formation of U- and V-shaped profile during OCT after 1 month was noted in all cases. The data obtained demonstrate the peculiarities of using the inverted ILM flap and ACP methods in comparison with the traditional method of MH closure with a gas-air mixture.

No abstract

No abstract