The antimicrobial activity of kanamycin, kanendomycin, gentamicin, amikacin, sisomicin, and dibekacin against 200 strains of Pseudomonas aeruginosa was compared. Dibekacin was found to be the most active against the tested organisms, whereas the other aminoglycoside antibiotics fell in the following order of diminishing antibacterial potency: amikacin, sisomicin, gentamicin, kanendomycin, and kanamycin. Seven strains showed high-level resistance to gentamicin (miniimal inhibitory concentration, 400 ,ug/ml), and two ofthem were also resistant to amikacin and sisomicin (minimal inhibitory concentration, 75 ,ug/ml). The miniimal inhibitory concentration of dibekacin for these seven strains was 0.625 Ag/ml. This study was carried out to compare the in vitro antibacterial activity of six aminoglycoside antibiotics, kanamycin, kanendomycin, gentamicin, amikacin, sisomicin, and dibekacin, against 200 strains of Pseudomonas aeruginosa of an overnight culture in nutrient broth, containing approximately 105 colony-forming units.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.