Objective Generalist health professional training on substance abuse prevention is patchy. This study assessed the effects of Project MAINSTREAM, a national interdisciplinary faculty development fellowship program, whose principal objective was to enhance curriculum on basic substance abuse services at health professions training institutions. Five interdisciplinary teams of three health professions' faculty were selected as fellows. This study assessed changes in curriculum, training, fellows' knowledge, and fellows' academic productivity in substance abuse. Design Pre-and post-program surveys and interviews were administered. Setting Fellows were located in five cities in the USA. Method The two-year, part-time training program featured training meetings, on-site and distance mentoring, and internet-based instructional materials. Principal learning activities consisted of developing independent projects in curriculum enhancement and prevention services delivery.

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