Reflection seismic and borehole geophysical data place important constraints on the subsurface geometry of the Sudbury Structure, which is the site of the world's largest Ni‐Cu camp. Seismic reflections can be traced from outcrop within the Sudbury North Range to about 4.5 km depth beneath the center of the Sudbury Basin, where the layer thickens abruptly from 1 to 3 km. Further south the North Range norite can be followed to about 10 km depth beneath the South Range. Borehole studies show systematic variations of p‐ and s‐wave velocity, Poisson's ratio and density within the Igneous Complex. Quartz‐rich granophyre is distinguished from the norite and footwall rocks by relatively low Poisson's ratios (0.20–0.23 versus 0.23–0.25). These changes in physical rock properties define an important subdivision of the Igneous Complex, compatible with a simple model involving differentiation of melted crustal rock into dominantly felsic and mafic components. This study documents the importance of interlayering to the seismic reflection response of the crystalline crust.