The circular polarization of light scattered by biological tissues provides valuable information and has been considered as a powerful tool for the diagnosis of tumor tissue. We propose a non-staining, non-invasive and in-vivo cancer diagnosis technique using an endoscope equipped with circularly polarized light-emitting diodes (spin-LEDs). We studied the scattering process of the circularly polarized light against cell nuclei in pseudo-healthy and cancerous tissues using the existing Monte Carlo method. The calculation results indicate that the resultant circular polarizations of light scattered in pseudo tissues shows clear difference in a wide range of detection angle, and the sampling depth depends on those detection angles. The structure of the endoscope probe comprising spin-LEDs is designed based on the calculation results, providing structural and depth information regarding biological tissues simultaneously.Template for JJAP Regular Papers (Jan. 2014) 2

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