This investigation was carried out at the Agricultural Station of the National Research Centre at Shalakan, Kalubia Governorate, Egypt. through two successive seasons (1997/98 and 1998/99) to study the influence of some herbicides on barley yield, yield components and the common associated weeds. The results showed that hand weeding and Isoproturon as well as Bentazon at the high dose were very effective in controlling the most annual weeds up to 80 days after barley sowing in both seasons. Chlorotoluron, Bentazon and Bromofenoxin as well as hand weeding treatment gave the best broad-leaved weed control more than the other treatments. While, Isoproturon and hand weeding treatments showed the best grass weed control in both seasons compared to the other treatments. Foliar application of Isoproturon at 0.650 kg a.i./fed, Bromofenoxin at 0.500 kg a.i./fed and hand weeding treatment improved the growth of barley plants and produced the tallest plants, the highest values of number of spikes/m², spike length, number of spikelets/spike, the heaviest weight of 1000-grain and the highest grain and straw yields/fed compared with the other treatments in both seasons. All weed control treatments achieved an increase in protein, phosphorus, potassium and total carbohydrates percentage of barley grains when compared with unweeded check.