Aim - аnalysis and evaluation of efficiency of anti-epidemic, preventive actions for decrease of plague infection risk for the population and prevention of this illness export outside the Republic Altai limits. Analysis was performed by the data of practical and research Establishments of Rospotrebnadzor. Due to occurrence of three epidemic plague foci in local population in Gorno-Altai natural focus where the infection source was an Altai marmot, the complex of organizational, anti-epidemic, preventive actions was performed for its localization and liquidation and also minimization of risk of anthropogenous plague distribution in Republic Altai and its exportation from the endemic region. Interaction of the Services and Departments in realization of organizational, anti-epidemic, preventive actions in Kosh-Agach district created the necessary conditions for localization, liquidation of the epidemic plague foci in the shortest terms, prevented the illness distribution by the anthropogenous way and its exportation outside the limits of the enzootic territory.