Background: Menopause is described as the discontinuation of menstruation for 12 months or longer. Women who experienced menopause often present with some symptoms associated with menopause. Menopausal symptoms are a serious problem in menopausal women as menopausal symptoms suffered by some women can interfere with their quality of life. Metabolic syndrome refers to a group of metabolic disorder that increase the risk of cardiovascular disease and type 2 diabetes. The development of metabolic syndrome is affected by both genetic and environmental factors. Objective: The purpose of this study was to determine the clinical profile of postmenopausal women with a genetic predisposition to metabolic syndrome. Materials and Methods: This is a cross-sectional study using the total sampling method in a population of postmenopausal women from 3 communities in Batam, Makassar, and Surabaya. The research was conducted online using a questionnaire. Result: Researchers selected 70 postmenopausal women. Of the 70 respondents, the average age of the respondents was 55.66 ± 4.24 (SD) years. The mean age of the respondents at menopause was 50.01 ± 3.57 (SD) years. The majority of respondents in this study had menopause for 1 -5 years. The job that most respondents had was as a civil servant. The majority of respondents have a university level of education. The number of respondents who are in income group 3 and group 4 is the same. Most of the menopausal symptoms experienced by respondents were physical and mental exhaustion followed by joint and muscular discomfort. The most common genetic predisposition of the metabolic syndrome component suffered by respondents in this study was central obesity, followed by hypertension. The highest prevalence of metabolic syndrome components suffered by respondents is central obesity, then hypertension. Based on the hypothesis test using chi-square on the genetic predisposition of the metabolic syndrome component and the metabolic syndrome component on menopausal symptoms, there was no significant correlation between the variables tested (P value > 0.05) Conclusion: There was no significant correlation between the genetic predisposition of the metabolic syndrome component variable and the metabolic syndrome component variable on the menopausal symptoms variable.