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Our chemical and pharmacological experimental programme8'9 in the field of substituted piperidines led to the discovery that 4-(4-hydroxy-4-phenylpiperidino)butyrophenone (I: L = R = H) was a powerful CNS depressant in various species. This unexpected result led us to investigate the CNS depressant properties of a new series of over 500 related basic ketones. The relevant chemical and pharmacological results obtained with these compounds will be presented and discussed in this series of papers.The purpose of this paper is to describe a convenient method of synthesis and some physicochemical properties, as well as some relevant CNS depressant properties in mice of a selected group of

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