The estimated economic burden of anastomotic leakage following AR is approximately double that of the remunerated tariff.

Actinomycosis of the testicle is a rare clinical entity. A review of the literature reveals only 7 case reports. Patients require prolonged therapy with antibiotics, usually penicillin. Many patients with less severe forms of the disease improve on antibiotics alone. Surgical intervention is reserved for confirming the diagnosis, treatment of abscesses, excision of sinus tracts and drainage. We report case 8 in the literature and review the previous reports.

Communicated by Garry R. CuttingResearchers and clinicians ideally need instant access to all the variation in their gene/locus of interest to efficiently conduct their research and genetic healthcare to the highest standards. Currently much key data resides in the laboratory books or patient records around the world, as there are many impediments to submitting this data. It would be ideal therefore if a semiautomated pathway was available, with a minimum of effort, to make the deidentified data publicly available for others to use. The Human Variome Project (HVP) meeting listed 96 recommendations to work toward this situation. This article is planned to initiate a strategy to enhance the collection of phenotype and genotype data from the clinician/diagnostic laboratory nexus. Thus, the aim is to develop universally applicable forms that people can use when investigating patients for each inherited disease, to assist in satisfying many of the recommendations of the HVP Meeting [Cotton et al., 2007]. We call for comment and collaboration in this article. Hum Mutat 28(10), [931][932] 2007. KEY WORDS: mutation; variome; recommendations; phenotype; genotype Communities of those caring for patients with inherited diseases have identified several important problems that impede the generation and flow of useful genotype/phenotype information to assist them in genetic research and healthcare. Most importantly, there is the problem that clinical details (phenotype) are often disconnected from the mutation found (genotype). Ideally, clinical phenotype information would be passed from the clinician to the diagnostician and back, and then in a suitably anonymized form in the public arena where it could be used by others, as it is important for diagnostic and therapeutic decisions. This proposal is particularly aimed at those who assess the patients and order the tests.

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