Glomerular filtration rate (GFR), cardiac output, regional blood flow and kidney weight were measured in alloxan and streptozotocin diabetic rats at different times after the administration of diabetogen. A high GFR was found together with increased kidney weight and reduced blood flow.

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Background. The available information on risk factors for childhood obesity is scarce compared to that for adults, and the progression of impaired fasting glucose (IFG) to type 2 diabetes in obese children has not been systematically investigated. However, the transition from prediabetes to type 2 diabetes is more rapid in children and adolescents than in adults.Objectives. The objectives were to assess the prevalence of IFG in obese children using their fasting blood glucose (FBG) levels and to test the validity of the hbA 1c level as a measure of IFG. Material and methods. This cross-sectional study included 412 obese children 6 to 18 years of age from two primary healthcare centers in Baghdad, with a BMI ≥ the 95 th percentile according to their gender and age. Data (age, weight, height, BMI, FBG, HbA 1c and family history) was collected over two interviews three days apart. Results. IFG was found in 8.9% of boys and 6.3% of girls, and a significant association was found between gender and IFG (p < 0.001). The hbA 1c level of the boys and girls in the cohort with IFG was inconclusive, as the results bordered on normal values. Conclusions. Obesity is a risk factor for IFG, and fasting blood sugar is the test of choice for the early detection of type 2 diabetes. The hbA 1c level was not a valid measure of IFG in this study. Larger samples may be needed to detect reliable results for HbA 1c as a valid measure of IFG.