Subjective well-being is an important factor of mental health. Reduced levels of subjective well-being inevitably lead to the formation of adverse mental states, which dictates the need for its early diagnosis. Diagnostics with psychological measurement (test) cannot be timely possible, as a rule, only after reaching adolescence. For this reason expedient search for genetic predictors of subjective well-being by identifying the association between the characteristics of subjective well-being and polymorphic loci related genes, encoding proteins involved in the formation of emotional states. These candidate genes are COMT encoding the catechol-o-methyltransferase and DTNBP1, encoding distrobrevin-binding protein-1. As a result of this work could be shown that polymorphic variants rs4680 COMT gene, rs2619522 and rs1018381 DNTBP1 gene may be involved in the genetic predestination of formation of psychological traits as affective and cognitive-affective components of subjective well-being, experience greater happiness in comparison with other people, enthusiasm, the integrity of nature, the ability to see the perspective.

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