Laminitis occurred in more clinically compromised horses. Use of ICE reduced the incidence of clinical laminitis in the study population suggesting that digital cryotherapy is an effective prophylactic strategy for the prevention of laminitis in horses with colitis.

No abstract

Lamellar tissue expresses IGF-1R, InsR isoforms and Hybrids. The functional characteristics of these receptors and their role in endocrinopathic laminitis warrants further investigation.

A n aged (estimated 28-year-old) Arabian mare was referred for evaluation of colic. On the day before presentation, the mare was lethargic with a decreased appetite, prompting administration of flunixin meglumine a (0.5 mg/kg, PO) by the owner. On the morning of admission, the mare was found recumbent in the stall with evidence of rolling during the night. Examination by the referring veterinarian revealed a normal rectal temperature (101.0°F), tachycardia (84 beats/ min), tachypnea (50 breaths/min), and bright pink oral membranes. Rectal examination findings were normal, but 8 L of gastric reflux were recovered on passage of a nasogastric tube. Flunixin meglumine b (1.1 mg/kg, IV) was administered before referral. Additional history included that the mare was in poor body condition when acquired 2 years previously. The mare's condition improved over the following 6 months. No prior colic episodes were reported.On presentation, the mare was lethargic but responsive. Rectal temperature was normal (99.8°F), but heart (100 beats/min) and respiratory (50 breaths/min) rates were increased. The mare stood quietly in the stocks and did not show obvious signs of abdominal pain. Oral membranes were bright pink and borborygmi were decreased in all quadrants. Extremities were cool and peripheral pulses, including digital pulses, were difficult to palpate. A few small, dry fecal balls were passed shortly after admission, but rectal examination did not reveal any abnormalities. A nasogastric tube was passed and 10 L of gastric reflux were obtained. Weight was 393 kg and body condition score was 6/9.Transabdominal ultrasonographic examination revealed the stomach to extend to the 16th intercostal (IC) space, but no other abnormalities were found. Abdominocentesis yielded a straw-colored peritoneal fluid; only a mild increase in TS was quantified by refractometry (2.8 g/dL; reference interval [RI] <2.5 g/dL). A rapid blood chemistry analysis revealed hyperglycemia (133 mg/dL; RI 85-115 mg/dL), mild hypernatremia (142 mmol/L; RI 135-140 mmol/L), decreased ionized Ca ++ concentration (4.7 mg/dL; RI 5.6-6.1 mg/dL), increased lactate concentration (3.3 mmol/L; RI <0.8 mmol/L), and azotemia (BUN 31 mg/dL; RI 15-25 mg/dL; Cr 2.7 mg/dL, RI 0.6-1.6 mg/dL). A CBC revealed increases in PCV (57%; RI 30-45%) and TS (8.3 g/dL; RI 5.9-7.5 g/dL) and a mature neutrophilic leukocytosis (segmented neutrophils, 12,230/lL; RI 1,940-7,400/lL) with a total leukocyte count of 13,250/lL (RI 5,100-13,120/lL). Estimated fibrinogen concentration (heat precipitation method) was mildly increased (0.5 g/dL; RI 0.2-0.4 g/dL).Initial treatment consisted of IV fluid therapy (a 2 L bolus of 7.2% NaCl solution followed by LRS supplemented with calcium borogluconate [50 mL/L of a 23% solution] and dextrose [20 g/L] at 5 mL/kg/ h), oxytetracycline HCl c (6.6 mg/kg, IV, q24h), flunixin meglumine b (0.5 mg/kg, IV, q12h), and lidocaine HCl d (1.3 mg/kg, IV bolus, followed by a continuous rate infusion [CRI] of 0.05 mg/kg/min, IV). The mare's feet were placed into ic...

This study demonstrates that a screening examination will be most likely performed if it is done as an on-site examination. In contrast, the participation rate is low if the patient has to make an appointment by himself. Acceptance of FS screening is also dependent on the patient's gender and family history of cancer. Additional strategies are needed to further improve participation.