No abstract

Developing options of the psychopharmacology require specialists to conduct goal-oriented and adequate therapy. The objective of the research was a comparative clinical and neurophysiological study of the action of amytriptyline, tyaneptine, fluoxetme and moclobemide, treating depressive disorders with the dominant affect of anguish. Totally, 107 depressed patients, aged 20-40, with depressive episode (38,3%), recurrent (53,3%) and bipolar (8,4%) affective disorders were clinically examined. Depression severity was assessed by clinical examination as well as by the administration of HAM-D Rating Scale and CGI Scale prior to and on the lOth, 20th and 40th days of treatment. Brainwave mapping was recorded before the therapy and on its 20th day. All patients were divided onto 4 groups: those, who were treated with amytriptyline (n=25), tyaneptine (n=28), fluoxetine (n=32) and moclobemide (n=22). Daily-dosages of amytriptyline (15&250 mg), tyaneptine (37.5-50 ma). fluoxetine (40-60 mz) and moclobemide (450-600 ma) depended on the depression &erity (moderate or severe levels). Control group consisted of 25 healthy people. Results of the study showed: when registering brain bio-electric activity of depressed patients prior to the treatment in comparison with the healthy group we have observed zones of "increased" activity in the right temporal fields and zones of "decreased" activity in the left temporal fields. Changes, occurring in these zones in response to the treatment, were more stable. Affecting the brain electric impulses all used agents demonstrated a similarity (core pattern) as well as the differences. All antidepressants reduced the activation of the right temporal zone and increased the activation of the left temporal zone. As a specific feature of the action, fluoxetine and moclobemide produced more significant increasing of the left temporal zone's activation. Amytriptyline caused an expanding of the activation zone from the left temporal fields to parietal and occipital fields. Tyaneptine produced migrating zones of activation.

Study Objective: To attempt to impair steady pathological condition (depression with depersonalization) with harmonic sounds in order to potentially reduce or eliminate both depression and depersonalization. Study Design: descriptive study, clinical and physiological study. Materials and Methods. We examined 31 patients aged 18 to 40 years (mean age: 29.3 ± 1.2 years) with a depressive episode in recurrent depressive disorder. All patients had background electroencephalogram (EEG) (16 channels) recorded. Then, EEGs were subjected to spectral analysis using Brainlog, which identified maximum extremes (with the amplitude exceeding adjacent harmonic frequencies) and minimum extremes (with the amplitude lower than adjacent harmonic frequencies). Clinical condition of patients was assessed following each piece of sounds (using subjective feelings). Hamilton depression scale was filled out before first sounds and after the session (4–6 sound pieces). Each patient had 5 to 15 sound exposure sessions. Study Results. A stable result after 15 sessions of harmonic sounds was absent in 9 (29.03%) cases. 5 (16.13%) subjects had complete remission with depersonalization reduction after harmonic sound exposure, that did not recur during 6-month follow-up. Partial remission was recorded in 17 (54.84%) individuals. During the 6-month follow-up, only one patient with asthenic remission did not have any antirelapse treatment. The other 16 subjects had anti-relapse treatment. Complete remission with elimination of depersonalization was recorded in 4 cases; 10 other observations demonstrated fluctuating depressive symptoms. Bad mood could cause depersonalization, but it was less marked. Stable depersonalization disorders, independent of depressed mood, persisted only in 2 individuals. Conclusion. Exposure to harmonic sounds in accordance with minimum and maximum extremes (repetition factor 2n) results in reduction or complete disappearance of depression with depersonalization in 70.97% of cases. The recorded reorganisation of amplitude-frequency fluctuations and all EEG rhythm intensity facilitate impairment of stable pathological associations in brain. Keywords: depression, depersonalization, harmonic sound.

Conclusion:The choice of methods of psychopharmacotherapy and psychotherapy in the greater degree was determined by premordid traits of personality.

Цели исследования: 1) выявить в системной организации клинических симптомов и характеристик электроэнцефалограммы (ЭЭГ) больных с депрессивными расстройствами жесткие и гибкие звенья; 2) определить, каким образом гармоническое звучание в соответствии с экстремумами максимум и/или эстремумами минимум спектра ЭЭГ влияет на структуру жестких и гибких звеньев клинических симптомов и ЭЭГ-характеристик; 3) найти взаимосвязь жестких и гибких звеньев клинических симптомов и ЭЭГ-характеристик; 4) изменяя режим звучания, расшатать клинические и нейрофизиологические устойчивые патологические связи, чтобы ослабить клиническую картину заболевания. Дизайн: открытое сравнительное исследование. Материалы и методы. Обследованы 57 пациентов с рекуррентными депрессивными расстройствами. Использовался факторный анализ с ротацией фактора. Результаты. Положительный результат терапии у всех пациентов, а также реакция на звук последнего сеанса звукового воздействия, уменьшение количества сеансов зависели от успешного устранения устойчиво взаимосвязанных клинических симптомов (жесткого звена системной организации), отражающих реципрокность собственно депрессивных симптомов с тревожными. Устойчивые связи (жесткое звено системной организации) ЭЭГ-характеристик не выявлены. У всех больных гармоническое звучание вызывало значительную перестройку спектра ЭЭГ и в момент звучания, и после него. Выявлена положительная роль при становлении полной или неполной ремиссии волн дельта-диапазона. Заключение. Примененный в данном исследовании системный подход к изучению депрессии, стремление прервать патологически устойчивое состояние гармоническим звуковым воздействием-это попытка дополнить понимание клинических и клинико-физиологических механизмов депрессивных расстройств с учетом их мультифакторного характера. Однако нейрофизиологическое жесткое звено системной организации ЭЭГ-характеристик обнаружить не удалось. Ключевые слова: гармонический звук, электроэнцефалограмма, депрессия, устойчивые клинические ЭЭГ-связи.