Objective. To analyze the work of the Republican Perinatal Council in the Republic of Sakha (Yakutia). Materials and methods. A retrospective analysis of the work of the Republican Perinatal Council in the Republic of Sakha (Yakutia) for 20182021 was carried out. Results. A total of 1553 women were sent to the RPC in 20182021. The proportion of group 2 women with changes in biochemical screening, chromosomal and hereditary fetal pathology increased. According to the results of RPC, the routing of pregnant woman is clearly worked out. The effectiveness of RPC can be estimated by the infant mortality rate in the Republic of Sakha (Yakutia) (2021 3.6 %). Conclusions. The work of the Republican Perinatal Council, strict control over the observance of the stages of obstetric care, the introduction of routing sheets in the Republic of Sakha (Yakutia), the concentration of pregnant women and women at high risk for maternal and perinatal pathology in third-level institutions allowed to reduce an early neonatal mortality, infant mortality.