No abstract

Previously reported acoustic metasurfaces that consist of fixed channels, are untunable to meet the broadband requirement and alterable functionalities. To overcome this limitation, we propose screw-and-nut mechanism of tunability and design a type of continuously tunable acoustic metasurface with unit components of helical cylinders which are screwed into a plate. The spiral channel length can be tuned continuously by the screwed depth; and then a metasurface with continuously tunable acoustic phase at independent pixels is attained. Different distributions of the unit components can shape an arbitrary metasurface profile. We also developed an approximate equivalent medium model to predict the tunability of the unit component.As an example, we present the design details of a circular tunable metasurface for three-dimensional acoustic focusing of different airborne sound sources in a wide frequency region. A sample of the metasurface is manufactured by poly lactic acid (PLA) plastic with the helical cylinders being 3D-printed. Experiments of sound focusing are performed. It is shown that the results of the equivalent medium model, the finite element simulation and the experiments are in a good agreement.

A severe limitation of current acoustic metasurfaces remains in their modest tunability to meet multi-frequency requirements and alterable functionalities on demand. Here, a reconfigurable curved acoustic metasurface for acoustic cloaking and illusion is reported. The structure is composed of an array of tunable helical units to break this limitation and realize continuously versatile sound manipulations. We theoretically, numerically and experimentally investigate the channel length represented by the helical depth, which is used to achieve full 2π phase shift continuously over the frequency range from 2 to 7 kHz. As pragmatic examples, we present by full-wave numerical simulations the concept of a curved metasurface for the continuously tunable acoustic multifunction, including broadband carpet cloaking and ground illusion at a wide working band. Then, we experimentally demonstrate these functionalities by showing an excellent effect to restore the disturbed reflective field from a cloaked object or to mimic an arbitrary shaped ground.

Abnormal metabolism of cancer cells results in complex tumor microenvironments (TME), which play a dominant role in tumor metastasis. Herein, self-delivery ternary bioregulators (designated as TerBio) are constructed for photodynamic amplified immunotherapy against colorectal cancer by TME reprogramming. Specifically, carrier-free TerBio are prepared by the self-assembly of chlorine e6, SB505124 (SB), and lonidamine (Lon), which exhibit improved tumor accumulation, tumor penetration, and cellular uptake behaviors. Interestingly, TerBio-mediated photodynamic therapy (PDT) could not only inhibit the primary tumor growth but also induce immunogenic cell death of tumors to activate the cascade immune response. Furthermore, TerBio are capable of TME reprograming by SB-triggered transforming growth factor (TGF)-β blockage and Lon-induced lactic acid efflux inhibition. As a consequence, TerBio significantly suppresses distant and metastatic tumor growth by PDT-amplified immunotherapy. This study might advance the development of self-delivery nanomedicine against malignant tumor growth and metastasis.