Original Research Article Resilience has emerged as a transdisciplinary concept in scientific research, being applied in a wide range of scientific disciplines. This study explores Organizational Resilience of the tourism hosting wineries. More specifically, it estimates Organizational Resilience scores of tourism hosting wineries using a composite index approach. Utilizing recent literature in the field, perceived Organizational Resilience is composed of perceived Planned and Adaptive Resilience, each of which is estimated using a group of Likert-scale statements. Using Crete as a case study, this study investigates the association of spatial characteristics of wineries, wine tourism entrepreneur"s profile as well as profile and management of wine tourism enterprises with the Organizational Resilience and its components. On average, the perceived Organizational Resilience and its components can be considered relatively high. Adaptive Resilience seems to be more important for Cretan tourism hosting wineries indicating that winemakers consider more important to adjust after crises rather than be ready to confront crises. In addition, nonparametric statistics reveal various factors that affect perceived Organizational Resilience and its components. Male entrepreneurs assign higher Adaptive Resilience scores than female, while geographical location seems to significantly affect resilience scores. Level of innovation and the size of the enterprise tend to positively affect resilience scores. On the contrary, family contribution in terms of labour negatively affects resilient scores, which could link to possible lack of expertise among family members regarding wine tourism activity. Finally, managerial practices like keeping records about visitors and wine bottle price segmentation also affect Planned and/or Adaptive Resilience scores.