achieved when Radiomics was used alone. The combination of Radiomics with addiction provided better AUC of 0.86 and accuracy of 88%. Accuracy for T staging was 60 % with AUC 0.81, while for recurrence combination of Radiomics, baseline ADC values and clinical addiction gave us best model with accuracy of 81%, AUC 0.76 and kappa of 0.45. (Details in table) Conclusion: The study is an effort to bridge the unmet need of translational predictive biomarkers in stratification of HPV positive OPSCC patients based on prognosis value. Radiomics features on imaging could be vital in deciphering molecular phenotypes, serve as tools for prognostication and predict recurrence.