The high abundances of Complex Organic Molecules (COMs) with respect to methanol, the most abundant COM, detected towards low-mass protostars, tend to be underpredicted by astrochemical models. This discrepancy might come from the large beam of the single-dish telescopes, encompassing several components of the studied protostar, commonly used to detect COMs. To address this issue, we have carried out multi-line observations of methanol and several COMs towards the two low-mass protostars NGC1333-IRAS2A and -IRAS4A with the Plateau de Bure interferometer at an angular resolution of 2 arcsec, resulting in the first multi-line detection of the O-bearing species glycolaldehyde and ethanol and of the N-bearing species ethyl cyanide towards low-mass protostars other than IRAS 16293. The high number of detected transitions from COMs (more than 40 methanol transitions for instance) allowed us to accurately derive the source size of their emission and the COMs column densities.The COMs abundances with respect to methanol derived towards IRAS2A and IRAS4A are slightly, but not substantitally, lower than those derived from previous single-dish observations. The COMs abundance ratios do not vary significantly with the protostellar luminosity, over five orders of magnitude, implying that low-mass hot corinos are quite chemically rich as high-mass hot cores. Astrochemical models still underpredict the abundances of key COMs, such as methyl formate or di-methyl ether, suggesting that our understanding of their formation remains incomplete.

We have analyzed rotational spectral line emission of OCS, CH 3 OH, HCOOCH 3 , and H 2 CS observed toward the low-mass Class 0 protostellar source IRAS 16293-2422 Source A at a sub-arcsecond resolution (∼0. 6 × 0. 5) with ALMA. Significant chemical differentiation is found at a 50 AU scale. The OCS line is found to well trace the infalling-rotating envelope in this source. On the other hand, the CH 3 OH and HCOOCH 3 distributions are found to be concentrated around the inner part of the infalling-rotating envelope. With a simple ballistic model of the infalling-rotating envelope, the radius of the centrifugal barrier (a half of the centrifugal radius) and the protostellar mass are evaluated from the OCS data to be from 40 to 60 AU and from 0.5 to 1.0 M , respectively, assuming the inclination angle of the envelope/disk structure to be 60 • (90 • for the edge-on configuration). Although the protostellar mass is correlated with the inclination angle, the radius of the centrifugal barrier is not. This is the first indication of the centrifugal barrier of the infalling-rotating envelope in a hot corino source. CH 3 OH and HCOOCH 3 may be liberated from ice mantles due to weak accretion shocks around the centrifugal barrier, and/or due to protostellar heating. The H 2 CS emission seems to come from the disk component inside the centrifugal barrier in addition to the envelope component. The centrifugal barrier plays a central role not only in the formation of a rotationally-supported disk but also in the chemical evolution from the envelope to the protoplanetary disk.