With one exception chloroimidazoles containing an unalkylated ring nitrogen have been ignored. Procedures are described using hypochlorite solution that permit the synthesis of 4,5‐dichloroimidazole and 2,4,5‐trichloroimidazole. Various bromoimidazoles are also converted to chloroimidazoles in refluxing hydrochloric acid.

HR 756 is a new cephalosporin derivative suitable for parenteral use. The compound possesses an unusally broad spectrum of antibacterial activity especially against gram-negative bacteria. Besides Escherichia coli, Salmonella, Klebsiella, indole-negative Proteae and other species also indol-positive Proteae, Serratia marcescens, Enterobacter and many Pseudomonas aeruginosa strains are inhibited by this compound. HR 756 is stable to most of the beta-lactamases produced by gram-negative organisms. Tests on different infection models also provided evidence of the high efficacy of HR 756 in vivo.

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