A new procedure has been developed for the synthesis of 3'-amino-3'-deoxyribonucleosides of adenine, cytosine and uracil by condensing the trimethylsilylated bases with peracylated 3-azido-3-deoxyribose derivative. The azido group could subsequently be reduced to amino. The 5'-phosphates of these nucleosides have been prepared and the analogues have been tested for their ability to stimulate the ribosome-catalyzed reaction of 3'(2')-O-(N-formylmethionyl) adenosine 5'-phosphate with phenylalanyl-tRNA.

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Aus dem Xylofuranose‐Derivat (I) wird nach Acylierung das Triflat (III) hergestellt, das mit Lithiumazid.

Ausgehend von Xylofuranose (I) wird über die Stufen des Disulfonats (II) und des Diazids (III) das Diazido‐ribofuranosediacetat (V) hergestellt und mit den Basen (VI) zu den Nucleosiden (VII) umgesetzt.