This study was conducted to determine the incidence of pathogenic with dental caries and antimicrobial susceptibility test of some common dentifrice sold in Kano metropolis. A total of 50 samples were used in this study. The samples were taken using swab from human oral mucosa. The swabs were in incubated at 37 0 Cfor 24h, as well as 48h. Dentifrices were also analyzed for the fluoride, phosphate, nitrite, potassium, chloride, carbonate, sulphate, calcium, sodium, and zinc contents using C: Varian/Cary Win Base Titration method, Gravimetry, and Air/Acetylene method. Of all the isolates, Streptococcus mutans was the most isolated pathogen with 24(30. .2mg/L. In the present study, it has been demonstrated that triclosan containing dentifrice are more effective in the control of pathogenic microorganisms associated with oral cavity compared to non-triclosan containing dentifrice.