Objective To assess the effectiveness and tolerability of eslicarbazepine acetate (ESL) monotherapy in routine clinical practice for the treatment of focal‐onset seizures. Methods Multicenter, retrospective, observational study conducted in patients older than 16 years treated with ESL as first‐line monotherapy or converted to ESL monotherapy from polytherapy or other monotherapy. Outcomes included 1‐year retention rate, seizure‐free rates after 6 and 12 months of monotherapy treatment, and safety/tolerability issues. Results A total of 256 patients were included (106 first‐line and 150 conversion to monotherapy; 56 patients aged >65 years). Overall, the 1‐year retention rate was 79% (72.7% in the ≥65 years subgroup) and seizure‐free rates at 6 and 12 months were 59.3% and 55.3% (72.2% and 67.3% in the ≥65 years subgroup), without significant differences when comparing first‐line vs conversion‐to‐ESL monotherapy groups (P = .979). However, the conversion group was heterogeneous and included 43 (29.1%) patients that were seizure free the year prior ESL introduction. A substantially higher proportion of patients remained seizure free for the entire follow‐up among those who initiated ESL due to tolerability problems compared with those treated due to inadequate seizure control (71.4% vs 37.3%). Overall, 62 of 256 (24.2%) patients reported AEs (39.3% in >65 years subgroup) and led to discontinuation in 20/256 (7.8%) patients (12.5% in >65 years subgroup). Commonly reported AEs were somnolence (6.6%), dizziness (6.3%), and headache (4.3%). Hyponatremia was recorded in five patients, the majority (4/5) of whom were older than 65 years. Conclusions Eslicarbazepine acetate was effective and well‐tolerated as first‐line or conversion to monotherapy in a clinical setting in adult and elderly patients with focal‐onset seizures.

Introducción: Los tumores glómicos son tumores benignos, poco frecuentes, localizados preferentemente en la mano, que presentan una clínica muy característica y cuyo tratamiento es quirúrgico. Material y métodos: Se han revisado retrospectivamente 75 tumores glómicos periungueales, diagnosticados clínicamente y confirmados por estudio anatomopatológico que fueron extirpados quirúrgicamente por vía lateroungueal. Resultados: El empleo de la vía lateroungueal para la exéresis de los tumores glómicos periungueales fue efectiva en todos los casos, sin originar distrofias ungueales y con un porcentaje de recidivas bajo (11,9%). Discusión: El diagnóstico de los tumores glómicos es fundamentalmente clínico, aunque se apoya en las pruebas de imagen (radiografía, ecografía y resonancia magnética). Su tratamiento es quirúrgico, existiendo múltiples vías de abordaje. Existe un riesgo de recidiva, que debe ser conocido por el paciente previamente a la cirugía. Conclusiones: El acceso lateroungueal en los tumores glómicos es un método seguro, que permite su exéresis completa.

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BackgroundChronic recurrent multifocal osteomyelitis (CRMO) is a rare autoinflammatory polygenic bone disease characterised by aseptic bone inflammation in paediatric population. Its management, clinical, radiological findings and treatment have not yet been standardised.ObjectivesRetrospective, descriptive multicentric study of patients diagnosed of CRMO in four tertiary level hospitals’ paediatric rheumatology section. There were 16 patients included. The clinical, radiological characteristics where analysed as well as response to treatment options.ResultsThe median age at diagnosis was 10,5 years, female:male ratio 62,5:37,5%. The delay in the diagnosis had a median of 4.5 months, being less than one year in 11 patients. Bone pain was the first symptom in 100% of the patients accompanied by fever in 25% of them. A single patient presented perilesional arthritis. A slight-moderate increase on acute fase reactants was observed at the debut of the disease: median ESR 47.5 mm/h.The median number of locations at debut was 2.5 (range 1–14), with multifocal involvement in 75%. The most frequent location was tibia (56%), followed by pelvis (44%) and vertebrae (31,25%). Other locations less fenquent were: carpus (12.5%), femur (12.5%) mandible (6%) and sternum (6%).Biopsy was performed in 14/16 patients and bone scintigraphy with Tc99 in 12/16 patients, with pathological uptake observed in 91.6% of cases. MRI was the radiological test of suspected diagnosis in 15/16 patients.NSAIDs were the initial treatment. 5 patients received different antibiotic therapy regimens, without clinical or radiological improvement. 56.25% of patients required other treatments. Systemic corticosteroids were used in 12.5% of patients and bisphosphonates in 43.75% (100% of patients with axial involvement). After 6 months of treatment with biphosphonates, 57.14% had complete remission, 28.57% partial remission and 14.28% worsening. 12.5% of the patients had a torpid evolution, receiving sequential therapies with multiple synthetic or biological DMARDs (Anakinra, Canakinumab, Etanercept), and another 12.5% required surgery.ConclusionsThe diagnosis of CRMO is a challenge in the absence of pathognomonic features which leads to delay in diagnosis and the initiation of treatment. In our centres the biphosphonates were the treatment strategy used in patients with spinal involvement with 85.67% response at 6 moths.Disclosure of InterestNone declared