The description of Kilaasa dates back 3,518 years ago. It is mentioned in Vedic texts like Atharva-veda (1500 BC) and Manu-smriti (1250 BC -1000 BC). Etiopathology, symptoms and management of this disease is mentioned in all major samhitas, manusmriti, Atharva-veda, dermatology textbooks. It is a non-contagious skin disease characterized by whitish patches on the body. Shirt, Darun and Aruna are its synonyms. Incompatible diet, excessive sun exposure and inapt social behaviour are mentioned as causes of Kilaasa in ayurveda literature. However, exact cause of Kilaasa remains un-known until date. In this disease, aggravated three doshas (bodily humors) vitiate rakta, maamsa and meda dhatu of the affected skin. Three sub-types of Kilaasa are based on colour of the patch. Shodhana and shamana are principal treatments of Kilaasa. Under the shodhana therapy, three processes are described for this disease. Vamana(emesis) and virechana karma are mentioned in all three samhita of brahatatrayi while Raktamokshana has been advocated in Astang Hradya only. Ayurvedic etiology, pathology and treatment of the Kilaasa are similar of the maha kushtha and kshudra-kushtha. The symptoms are similar to the Vitiligo described in the modern text.