The paper presents a comparative analysis of three solutions of the power supply topology of a high-efficiency hybrid vehicle. The analysis was carried out for the Hydros prototype vehicle developed at the Lublin University of Technology for the Shell Eco Marathon competition. This vehicle is driven by an electric motor powered by two energy sources: hydrogen fuel cells and supercapacitors, allowing temporary energy buffering. Three variants of the mutual connection of the two energy sources to a single receiver were analysed, taking into account the voltage converter systems between the individual components of the system. The aim of these analyses was to determine the most energy-efficient solution.