BackgroundIn addition to the extra-articular manifestations associated with spondyloarthritis such as IBD, psoriasis and uveitis, spondyloarthritis is linked to an increased risk of comorbidities.ObjectivesTo study the prevalence of comorbidities in spondyloarthritis (SPA) at inclusion and 36-month follow-up and their influence on disease activity and functional outcome in a cohort of patients followed for SPA from the Moroccan registry of biological therapies in rheumatic diseases (RBSMR Registry).MethodsData were analyzed from cohort of 194 patients with SPA from the RBSMR Registry including comorbidities (hypertension, diabetes, dyslipidemia, obesity, osteoporosis, sedentary lifestyle, gastrointestinal ulcer, smoking, depression, fibromyalgia) and disease activity scores at inclusion (M0) and at 36-month follow-up (M36).ResultsThe mean age was 40,23 ± 13,68 ans. The sex-ratio (M/W) was 1,73. 96.4 % of the patients had axial involvement, 70 % had peripheral involvement and 61.5 % had enthesitis. SPA was radiographic in 88.1 % of the cases. The mean duration of disease was 615,90 ± 349,12 weeks. 57,2% of patients had at least one comorbidity, among whom the median comorbidity count was 1 (range 1-5).Table 1.comparison between prevalence of comorbidities at M0 and M36.ComorbidityPrevalence at inclusion (M0)Prevalence at 36-month follow-up (M36)Sedentary behaviour29,4% (n=57)31,4% (n=61)Osteoporosis11,3% (n=22)13,4% (n=26)Smoking10,8% (n=21)10,8% (n=21)Hypertension5,7% (n=11)9,3% (n=18)Obesity8,2% (n=16)8,2% (n=16)Tuberculosis6,7% (n=13)11,34% (n=22)Diabetes5,2% (n=10)6,2% (n=12)Gastrointestinal ulcer2,6% (n=5)3,1% (n=6)Dyslipidemia1,5% (n=3)2,6% (n=5)Cancer0% (n=0)1,0%(n=2)Depression2,6% (n=5)2,6% (n=5)Fibromyalgia2,1% (n=4)2,1% (n=4)Table 2.Comparison between patients with or without comorbidities.ParameterPatients with at least one comorbidity (57,2%)Patients without comorbidities (42,8%)pESR (mm/h)36,2436,970,163CRP (mg/l)42,1427,000,002ASDAS-CRP3,672,500,003BASDAI5,104,500,098BASFI6,104,160,028ConclusionIn our study, the presence of comorbidities was correlated with more severe disease activity. Better management of these comorbidities may result in better outcome of patients with SPA.REFERENCES:NIL.Acknowledgements:NIL.Disclosure of InterestsNone Declared.

BackgroundSpondyloarthritis (SPA) is a chronic inflammatory rheumatism characterized by sacroiliitis and spinal involvement, affecting both genders but more frequent in males.ObjectivesThe aim of this study is to analyze the epidemiological, clinical and paraclinical characteristics of Spondyloarthritis in women.MethodsRetrospective study included 333 patients followed up for SPA at the Rheumatology Department between 2004 and 2021.ResultsOur study involved 153 women and 180 men. In the female population, the mean age was 45.1 years, 12.4% had high blood pressure, 4.8% had a psychiatric comorbidity and none of the patients were smokers, versus a mean age of 36.4 years, 5% of high blood pressure’s patients, 1.7% having a psychic comorbidity and 25% of the smokers for the male with SPA. The age of onset of symptoms was 36.5 years for women versus 28 years for men (p =0.001). Axial involvement was 84.3% in women and 85% in men, while peripheral and enthesial involvement was present in 73.8% and 56.8% of female subjects and 58.8% and 46.6% of male subjects (p at 0.004 and 0.064 respectively). Coxitis was present in 13.1% and syndesmophytis in 15.3% of females versus 36.1% and 18.3% of males (p at 0.001 and 0.4 respectively). Mean erythrocyte sedimentation rate was 45.7, mean CRP 28.5 and mean calcemia 92 in the 1st group versus 43, 40.6 and 93.4 in the 2nd (p at 0.4; 0.03 and 0.03 respectively). Relapse was 26.8% in female with SPA and 12.6% in male (p =0.025)ConclusionIn our study, females SPA patients developed symptoms later than did males, peripheral and enthesial involvement is more common in females while coxitis is more common in males with statistically significant higher CRP and calcemia.References[1]Rusman T, van Vollenhoven RF, van der Horst-Bruinsma IE. Gender Differences in Axial Spondyloarthritis: Women Are Not So Lucky. Curr Rheumatol Rep. 2018 Jun;20(6).[2]Sboul S, Nassar K, Janani S. La spondylarthrite féminine: particularités cliniques et paracliniques. Revue du Rhumatisme. 2021 Dec;88:A266.Disclosure of InterestsNone declared