Degradation of cetirizine in polyethylene glycol arose from the reaction between the drug and the reactive peroxide intermediates such as peroxyl radicals formed through oxidation of PEG. Selective oxidation of cetirizine and isolation/characterization of the oxidation product allowed the identification of the oxidation product as cetirizine N-oxide. The mechanism of oxidation is proposed.

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Glucosinolates are a class of sulphur containing glycosides found throughout the Brussica species and are of considerable interest to the breeder and to the processor because of the physiologically active nature of their enzymically-produced breakdown products.Although almost 100 glucosinolates are now known (differing only in the nature of the side-chain R), far fewer (perhaps 12-20) are of significant occurrence in brassicas, often with only 4-8 major compounds present in any one species.' December, I984QUALITY CONTROL OF FOODS AND NATURAL PRODUCTS 483

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