The correlations between semi-automated sputum cytometry (ASC), conventional cytology and the final diagnosis was investigated in industrially-exposed workers. Slides of sputum samples from 201 former uranium miners with silicosis, 100 patients with asbestosis, 103 workers resected for lung cancer, and 200 controls (50% smokers), were stained using the Papanicolaou (Pap) method and the Feulgen reaction with thionin. Cytometry was performed using the Cyto-Savant automated system. Atypical nuclei were found in 72 of 404 patient samples, 327 samples were normal and five were inadequate for ASC analysis. Thirteen tumours (Pap IV, Pap V) and 11 cases of severe dysplasia were identified by cytology. Lung cancer was confirmed in 20 patients. Compared to the final diagnosis of lung cancer, the sensitivity of ASC was 75% (15 out of 20) and specificity 89.8% (520 out of 579). The results represent a diagnostic efficiency of 89.3%. The combination of ASC with cytology increased sensitivity to 80% (16 out of 20) without significant loss of specificity (89.7% or 523 out of 581).In this investigation of a limited number of patients with occupational radon or asbestos exposure, semi-automated sputum cytometry appears to be sensitive and reliable for the detection of malignant changes in the tracheobronchial mucosa. Together with conventional cytology, it would be reasonable to test the validity of the combined methods in a large-scale feasibility study of early lung cancer detection. Eur Respir J 2001; 18: 942-950.

Pneumologie 53 (1999) W. Marek et al. 584Dieses Dokument wurde zum persönlichen Gebrauch heruntergeladen. Vervielfältigung nur mit Zustimmung des Verlages. Pneumologie 53 (1999) W. Marek et al. 588Dieses Dokument wurde zum persönlichen Gebrauch heruntergeladen. Vervielfältigung nur mit Zustimmung des Verlages.Proben befand sich zu wenig repräsentatives Material für die Befundung (0) (Tab. 1). Zytometrische Befundung im Vergleich zur histogenetischen TumorklassifikationDer Verdacht auf das Vorliegen eines broncho-pulmonalen Tumors konnte histologisch oder zytologisch bei 108 der 142 untersuchten Patienten in der Enddiagnose gesichert werden (Tab. 2). Unter den Tumoren waren kleinzellige Karzinome in 26 % der Tumorfälle vertreten, die davon untersuchten Präpa-rate waren alle zytometrisch auffällig. Unter den nicht-kleinzelligen Tumoren waren Plattenepithelkarzinome mit 23 %, Adenokarzinome mit 34 % und großzellige Karzinome in 8 % vertreten.Enddiagnose als "Goldstandard"Der Vergleich mit der abschließenden Enddiagnose aus sämt-lichen Untersuchungsergebnissen als "Goldstandard", zeigte

Objective: To assess the clinical and laboratory profile of RT-PCR positive covid-19 patients in district hospital in Bangladesh. Method: This cross-sectional study was done in 250 Bed General Hospital, Tangail, Bangladesh from January 2021 to Dec 2021. We included 95 patients having clinical symptoms and signs of COVID-19, above the age of 18 years, irrespective of sex. We defined probable and confirmed COVID-19 case according to ‘National Guidelines on Clinical Management of Corona Virus Disease 2019 (COVID-19) Version 7.0, published on 28 May 2020.10 Data were collected in structured questionnaire from patients and hospital records. All laboratory tests were performed according to the clinical judgement. Laboratory assessments consisted of RTPCR for COVID-19, complete blood count, coagulation tests, assessment of liver and renal function, C-reactive protein, procalcitonin, lactate dehydrogenase (LDH) and ferreting. Radiological assessments included chest x-ray and high resolution computed tomography (HRCT) scan. Results: During the study, majority were belong to >56 years age group, 43.6% were female and 56.4% were male. Plus, majority didn’t get their vaccination, 89.60%. In addition to that, 42.1% had DM followed by HTN cases was 36.8%, 8.4% had previously history of stroke, 10.5% had CKD. 69.5% had anorexia followed by 58.9% had nausea, 28.4% had vomiting, 14.7% had Abdominal pain. On laboratory investigations, we found most of the patients had elevated levels of C-reactive protein and D-dimer was positive in 99% cases. Plus,75% patient presents emergency signs with SpO2 <90% or respiratory rate >24. Conclusion: Considering the data of this investigation, it can be stated that, COVID-19 impacted mostly senior male patients. Most of them were diabetic and hypertensive. Common symptoms anorexia sore throat, diarrhea, vomiting, nausea, stomach ache. Key test results included lymphopenia, elevated CRP, positive D-dimer. Notwithstanding that most didn’t take ......

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