The role of underground research laboratories (hereinafter URL) is recognized globally and involves the following points: URL enables research and demonstration aimed at evaluating the feasibility of technological processes under actual spatial scales and geological setup. In recent years, quite a lot of articles and reviews was published [1][2][3][4][5], concerning the issues associated with URLs established to demonstrate the safety of radioactive waste deep geological disposal. It should be noted that 25 URLs were developed globally for various purposes. Most similar to the Russian one by their purpose are those being site-specific (located at potential disposal sites) and excavated in crystalline bedrock (granite and gneiss), namely: operating URL ONKALO (Finland) and the one planned for construction in 2020 in China (Beishan Province). Among all the publications there are several articles [6][7][8][9][10][11][12][13][14] focused on particular studies planned to be carried out in the Russian URL being under construction at the site of Nizhnekanskiy massif in the vicinity of Zheleznogorsk city (Krasnoyarsk region). This paper presents the designs of the Russian URL being for the first time ever discussed in a holistic and dynamic manner starting with the construction stage and up to the closure of the disposal facility.