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Peptides Peptides U 0400Synthesis and Anti-Dopamine Effect of Conformationally Restricted Analogues of the Dipeptide Neuroleptic Dilept. -Three dipeptides are synthesized, which represent βI-turn (Ib), βII'-turn (IIa) and βII-turn analogues (IIb) of the new neuroleptic dilept (Ia). Studies on the anti-dopamine effect of these analogues reveal that only the βI-turn analogue (Ib) containing the α-methyl group possesses biological activity higher than dilept itself, while the lactam-containing βII-turn analogues (II) are inactive. It is concluded that the βI-turn form of dilept might be the biologically active form. -(ZAITSEVA, N. I.; GUDASHEVA, T. A.; OSTROVSKAYA, R. U.; RETYUNSKAYA, M. V.; BONDARENKO, N. A.; IGNASHIN, A. N.; VORONINA, T. A.; Khim.-Farm. Zh. 37 (2003) 5, 3-6; GU NII farmakol., Ross. Akad. med. nauk, Moskva, Russia; Russ.) -Mischke 41-201

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