No abstract

We found a statistically significant correlation between the expression of p53, p21, Ki67 and the differential diagnosis of adrenal cortical adenoma and adrenocortical carcinoma (for proteins: p53 p=0.010, for p21 p=0.010, for Ki67 p<0.001). The statistical significant correlation between PCNA protein and diagnosis of adrenal cortical adenoma and adrenocortical carcinoma was not found. The statistically significant correlation between p21, PCNA proteins and the diagnosis of benign and malignant PHEOs was not estimated. There was no expression of Ki67 or p53 protein above the assumed level in benign and malignant pheochromocytomas. The statistically significant correlation between p53, p21, PCNA or Ki67 and the occurrence of metastases in adrenocarcinoma and malignant PHEOs was not found.

Results of this work show that a significant number of IP cases might have an autoimmune etiology. There was a positive correlation between activated stellate cell marker expression and the degree of fibrosis.

The pancreatic duct system in the body and the tail presents abnormal configuration not described in the past.

Introduction: The fourth edition of the WHO Classification of Tumours of the Urinary System and Male Genital Organs (2016) contains new renal tumour entities. These new subtypes of renal cell carcinoma (RCC) were introduced based on morphological criteria, some genetic features, and clinical characteristics with prognostic implications. We present three patients with rare renal tumours belonging to newly recognized or still emerging categories of RCC. All cases were diagnosed based on careful morphological examination with immunophenotyping, and patho-clinical correlation. The first case is an example of acquired cystic diseaseassociated renal cell carcinoma with heterogeneous architecture as well as specific intra-and intercytoplasmic microlumens. The second tumour a tubulocystic renal cell carcinoma-was composed of multiple, various-sized cysts divided by fibrovascular septa and tubules lined focally with hobnail cells. The third case presents very rare sporadic eosinophilic, solid, and cystic RCC. This tumour contained macro et microcystic, areas intermixed with solid fields composed of large, in part multinucleated eosinophilic cells. Inflammatory infiltrations accompanied the neoplastic stroma. New subtypes of RCC, although rare, can be encountered in everyday practice. It is important to perform careful differential diagnosis and classify such tumours according to the recent guidelines.