Maize (Zea mays L.) is one of the most important crops in East Africa serving both as a staple food and cash crop to millions of people. As a vegetable, it is produced as green maize cobs, sweet corn or baby corn. Yields under farmers' conditions in the Lake Victoria Basin average 1.3 t ha -1 which is less than 25% of the potential yield. This is attributed to several factors; the greatest being Striga (Striga hermonthica) which is a parasitic weed attacking several crops in the grass family. A medium term technological breakthrough in form of a herbicide (imazapyr) resistant maize variety has been developed to help reduce Striga infestation. The optimum maize plant population for effective seedbank reduction and optimum grain yield has however not been determined. The main objective of this study was therefore to evaluate the performance of imazapyr-resistant (IR) maize at different plant densities on Striga weed incidence and crop growth. The study was conducted for two seasons on a naturally infested Striga field in Western Kenya. The experiment was laid out as a split plot with three replications. Maize variety (treated IR maize, untreated IR maize and WH505/H516 commercial checks) was the main plot factor and density (44,444, 66,666 and 88,888 plants ha -1 ) as the sub-plot factor. Data was collected on maize stand, days to first Striga emergence, Striga incidence, Striga biomass, maize biomass and its yield components. Treated IR maize delayed Striga emergence on maize thus suppressing Striga parasitism. Any late Striga attachments had little or no effect on maize growth. Increasing the plant density of treated IR maize from 44,444 to 88,888 plants ha -1 did not affect Striga incidence but increased maize yield from 1.60 to 3.48 t ha -1. It is therefore recommended that treated IR maize should be planted in Striga infested fields at 75cm x 15cm to hasten Striga seed bank reduction and maximize on maize yield to improve staple food availability.