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A case of conventional intramedullary osteosarcoma (epithelioid subtype) with 10 years of evolution and another of high grade surface osteosarcoma of the chondroblastic type, both in the skull, gave rise to several diagnostic and therapeutic difficulties. Key points concerning the definition, classification, imaging, clinical series data and treatment options available for skull osteosarcoma are highlighted.

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Despite the name, gastrointestinal stromal tumor (GIST) is a mesenchymal gastrointestinal neoplasm that may occur outside the gastrointestinal tract. The correct characterization based on histological features and immunohistochemical expression of c-kit (CD117) has allowed targeted treatment for this kind of cancer and therefore improvements in the outcome. The authors present a rare clinical case of a GIST of the pelvic cavity with a long 10 years follow-up.