Flash visual evoked potentials (FVEPs) and brainstem auditory evoked potentials (BAEPs) were performed in 13 children (aged 3-17 years) affected by mucopolysaccharidoses (MPSs). FVEPs and BAEPs were abnormal in 6 and 9 patients, respectively. The presence of these abnormalities in most neurologically normal patients suggests that electrophysiological techniques provide a useful tool for detecting early abnormalities.
curative liver resections (LR) on the occasion of colorectal liver metastases (CRLM) were performed. Metachronous ware 142 patients and synchronous 156. Results: 103 major liver resections were performed, 50% in the synchronous group. The median survival of the entire group was 48.8 months, with a median of 20.63 months; synchronous-46.5 months, with a median of 27.3 and metachronous 42.28 months and 31.77 (p = 0.179). Fiveyear survival calculated by Life table is 33% for metachronous and 22% for synchronous (p = 0.225). In patients with synchronous metastases Cox analysis confirmed importance for the survival of the following factors: the volume of LR (p <0.003), distribution in the liver (p <0.015), volume of blood loss (p <0.013) and lymphovascular invasion (p <0.004). For operated with metachronous LM important factors for survival are the number and size of LM (p <0.022), distribution in the liver (p <0.019), the volume of LR (p <0.003), anatomic LR (0.012). Conclusion: Treatment of CRLM requires precise selection and individual approach undertaken by a multidisciplinary team. Applying advanced multimodal approach allows increasing the number of radically operated patients
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