Even though the treatment options are most available, incidence and recurrence of Renal calculi has not yet markedly reduced. The main aim of the study was to assess the efficacy of poly herbal formulation Sarva Noi Linga Chenduram for Renal calculi. It was diagnosed by clinical signs, symptoms ,the presence and size of renal calculi was confirmed by Ultrasonagram. It was an open labeled, single center, prospective, pilot study conducted in 20 patients of renal calculi in National Institute of Siddha.130 mg of Sarva Noi Linga Chenduram was given with Raphanus sativus juice after meals twice a day for 30 days. After the treatment period there were prognosis of symptoms statistical analysis-paired 't' test "P" value showed 0.240 which is moderately significant and for size of renal calculi it showed 0.001 which is highly significant. No significant change in most of the safety laboratory parameters was observed at the end of the study. Hence Sarva Noi linga Chenduram can be used in the treatment of Renal calculi.