Abstract. Coagulation studies including platelet count, partial thrombop]astin time, prothrombin index, and assays of fibrinogen, prothrombin, proaccelerin, antihcmophilic globuline and fibrin(ogen) degradation products were carried out in 12 newborn infants afflicted with septicemia. All patients had a decrease of platelet counts. 8 patients showed characteristic signs of DIC. In 3 cases we found marked consumption and in 3 other cases mild forms of DIC. In 2 cases DIC had occurred a few days before we obtained samples. The remaining 4 patients exhibited as a result of endotoxinemia a low platelet count without affecting blood coagulation. The most reliable laboratory findings for the diagnosis of DIC seem to be reduced platelet counts and low levels of fibrinogen and factor V. Poor prognosis and a high mortality rate still characterize cases of septicemia in newborn infants. The immunological situation, the absence of Ig A and Ig M, and a frequent deficiency of pathognomonic symptoms are the causes most frequently cited [17,18]. As thrombocytopenia is a frequent finding in the course of septicemia in newborn infants, we attempted to determine, whether this is due to disseminated intravascular coagulation (DIC). Thromboeytopenia associated with a decrease of certain plasma coagulation factors and with secondary Key-Words: