A number of 45 female rabbits were anesthetized, and intra-abdominal lesions were set at either of the uterine horns and the abdominal wall in a standardized technique. Before closure of the abdomen the collective--divided into three subgroups of 15 animals each--received i.p. one of the following pharmaca: Group I: solution of physiologic saline (control group) Group II: poly-1-vinyl-2-pyrollidon iodine complex Group III: streptokinase/streptodornase. Two weeks after the first operation a second laparotomy was performed, and the sites were inspected. The adhesions were examined and their quantity and quality documented. Statistical evaluation showed that groups I and II were significantly different from group III as to the extent and intensity of the adhesions.

Standardised lesions were placed on both uterine horns and on the abdominal wall of seventy-five female rabbits. The animals were divided into five groups consisting of 15 animals each. Before closure of the peritoneum the following drugs were applied in the peritoneal cavity: Group I received NaCl (control), Group II received 10 ml poly-(1-vinyl-1-pyrrolidone)-iodine complex (Betaisodona), Group III received 100 000 I. U. streptokinase and 25 000 I. U. streptodornase (Varidase), Group IV received 100 000 KIE approtinine (AntagosanA) and Group V received triamcinolone acetonide (Volon A-Haftsalbe). Two weeks after surgery the animals were relaparotomised and the situs was inspected. Quality and extent of the adhesions were assessed and documented. The results obtained in group II did not differ from controls, while the remaining groups showed significantly fewer adhesions. The best results were obtained in animals receiving Volon A-Haftsalbe (Group V) where 86% fewer adhesions were observed.