Serotonin syndrome is potentially life-threatening syndrome associated with excessive serotonergic activity within the central nervous system. Serotonin syndrome is associated with medication use, drug interactions, and overdose. While serotonin syndrome is often associated with the use of selective serotonin inhibitors (SSRI), an increasing number of reports are being presented involving the use of tramadol. With tramadol increasing popularity, the goal of this article is to make physicians more alert and aware of this potential side effect. Serotonin syndrome may be difficult to diagnose. A case of serotonin syndrome caused by the combination of tramadol and antidepressants in a patient with advanced cancer is presented and discussed. The importance of early diagnosis of this syndrome is emphasized.

Assessed the predictive validity of the Graduate Record Examinations (Advanced, Quantitative, and Verbal) in an archival study of graduate success in a psychology master's program. These tests and 5 other predictors (undergraduate GPA, letters of recommendation, undergraduate scholarships/awards, undergraduate teaching and/or research experience, and age) were correlated with 4 measures of graduate success: graduate GPA, graduate statistics course grade, time to completion of program, and a rating of program performance. Data from 55 student files indicated that the GREs, in particular the Advanced test score, were the best predictors for all but the time-to-completion variable. Multiple regression and discriminant function analyses supported the use of the GREs as predictors of success in this program. Ethical considerations regarding the use of the GREs in selection are also discussed. (French abstract) (19 ref)

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