It was a negative study with unexpected benefits of the drug only in females. We hypothesized that the role of patients' sex can impact the treatment response to serotonergic drugs in general. We suggest a possible synergistic interaction between estrogen and Avisetron by means of modulating the effect of estrogens on the serotonergic system. Future studies targeting the sex-related effects of serotonergic drugs are warranted.

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The aim of this work is to assess the influence of the climatic and weather characteristics of the South Coast of Crimea (SCC) on the effectiveness of health resort medical rehabilitation (MR) of patients with ischemic heart disease (IHD).Materials and methods. A study was carried out in a group of 276 patients with IHD. The influence of climatic and weather characteristics of the SCC were assessed using the methods developed by the «ARI n.a. I.M. Sechenov» - modified clinical index on weather pathogenicity (CIPP-M) and MR assessment according to the criteria of the» International classification of functioning, disabilities and health» (ICF).Results. Regression equations for the dynamics of the ICF b2401, b280, b4301 and b440 domains on the values of air temperature (AT-M), atmospheric pressure variability (APV), air temperature variability (ATV-M) wind speed (WS-M) and total CIPP-M have been developed, which allow to reliably form a rehabilitation prognosis for patients with IHD for all terms of health resort treatment in the SCC.Conclusions. The use of modernized clinical indices of weather pathogenicity allows one to adequately assess and predict the effect of weather dynamics and form a rehabilitation prognosis for patients with IHD.

Examination along with implant treatment was carried out in 21 patients with severe tooth wear on the occlusal surface. This disorder features a variety of clinical symptoms including changes in the facial features and the lower jaw movement amplitude, disturbed canine and incisor guidance, supercontacts, asynchronous operation of the masticatory muscles, etc. We have proposed a treatment algorithm aimed at eliminating these issues. The temporary non-removable dentures allowed creating occlusal marks (Stage 1) followed with their transfer onto permanent orthopedic structure (Stage 2) using implants. The complexity of the approach to treating this disease, as well as the effectiveness of our method has been confirmed by clinical data and the outcomes obtained through an instrumental study involving electromyography and electronic axiography. The extra additional research methods employed, such as electromyography and electronic axiography, allowed to assess the activity of masticatory muscles and the lower jaw articulation, thus to ensure occlusal-articulation interaction when restoring the lower facial height.

Aim. To assess the influence of the climatic and weather patterns at the South Coast of Crimea (SCC) on the effectiveness of health resort medical rehabilitation of patients with lung diseases (LD).Materials and methods. A study carried in a group of 197 patients with LD. The influence of climatic and weather patterns at the SCC were assessed using the methods developed by the Academician Research Institute of Physical Methods of Treatment, Medical Climatology and Rehabilitation named after I.M. Sechenov – modified clinical index on weather pathogenicity and medical rehabilitation assessment according to the criteria of the “International Classification of Functioning, Disability and Health” (ICF).Results. Regression equations for the dynamics of the ICF domains b280, b430, b4303 and for the mean value of all domains on the values of air temperature, wind speed, cloudiness, and air temperature variability have been developed, which allow to reliably form a rehabilitation prognosis for patients with LD for all terms of health resort treatment in the SCC.Conclusion. The use of modernized clinical indices of weather pathogenicity allows one to adequately assess and predict the effect of weather dynamics and form a rehabilitation prognosis for patients with LD.