In this study, the effect of posture, vibration magnitude and frequency on seat-to-head (STH) and back support-tohead (BTH) transfer functions has been studied under vertical sinusoidal vibration. Twelve healthy male subjects were participated in experimental work to measure vertical vibration transmitted to the occupants head in three representative postures (erect, vertical back on and forward lean on table) under three magnitudes of vibration (0.4, 0.8 and 1.2 m/s 2 r.m.s.) in frequency range 1 to 20 Hz. From collected data sets, the effect of vibration magnitude, vibration frequency and postures on STH and BTH transmissibility's and phase has been drawn over the prescribed frequency range. The result suggested that inclusion of all possible variables in optimal design of vehicle seat, suspension and comfort analysis most benefit for better design and analysis. The comparison of experimental and model response reveals that both models matched with mean experimental data sets most closely and the models provide best description about biodynamic response study of seated human subjects under vertical whole body vibration.

Aim To evaluate the role of Ga-68 fibroblast activation protein inhibitor 04 PET/computed tomography (FAPI) in colorectal cancers (CRCs) in terms of diagnostic accuracy and impact on clinical management. FAPI is compared with FDG PET/CT and conventional imaging in staging, restaging, recurrence detection, and response evaluation of CRC. Methods Twenty-nine consecutive patients of histopathologically confirmed primary or relapsed CRC were included in the study. Patients who underwent FAPI PET/CT along with either FDG PET/CT or conventional imaging were included. Primary lesions, recurrence sites, lymph nodes, and metastatic lesions were recorded on all the scans. Maximum standardized uptake value (SUVmax) was measured from both primary and metastatic lesions. Results The sensitivity of FAPI in primary and recurrence detection is 100% compared to 88% for FDG/conventional imaging. The overall sensitivity of FAPI stands at 98% with accuracy at 95% whereas for FDG/conventional imaging the sensitivity and accuracy are 78% and 77%, respectively, with P < 0.002. Significant difference was noted in the detection of peritoneal metastasis (96% vs. 66%). Conclusion FAPI PET/CT shows better sensitivity and accuracy in the evaluation of CRCs, especially in peritoneal disease compared to FDG PET/CT and conventional imaging. FAPI has the potential to replace FDG in CRCs.

A chronic venous leg ulcer is not so common in Ayurvedic practices. But deep vein thrombosis is more common in clinics. Venous and arterial diseases are most usual cause of leg ulcers accounting to 60 to 80% of them. On an average 33 to 60% of these ulcers are present for more than 6 weeks and therefore referred to as venous leg ulcers. The case reported here was as a result of repeated trauma with a history since 20 years. The treatment was given at IPD level diagnosing it as Upadrava Roopi Vatarakta with valid Chikitsa Siddhanta. This case report provides us a guide lines that even a chronic ulcer can be healed with proper assessment of Dosha, Dhatu, Strotas involvement.

In Ayurveda, Jwara is not merely the concept of raised body temperature, but as is said in Charaka Samhita, 'Deha- Indriya- Manah- Santap' is the cardinal symptoms of Jwara. This can be defined as the state where the body, mind as well as sense oragans suffer due to the high temperature. Vishamajwara is a type of fever, which is described in all Ayurvedic texts. Charaka mentioned Vishamajwara and Chakrapani have commented on Vishamajwara as Bhutanubanda, Susruta affirmed that Aagantuchhanubhandohi praysho Vishamajware. Madhavakara has also recognised Vishamajwara as Bhutabhishangajanya (infected by microorganism). Vishamajwara is irregular (inconsistent) in it's Arambha (nature of onset commitment), Kriya (action production of symptoms) and Kala (time of appearance) and possesses Anushanga (persistence for long periods). The treatment of this disease depends upon Vegavastha and Avegavastha of Jwara. Various Shodhana and Shamana procedures are mentioned in classics to treat Visham Jwara.

Ayurveda essentially sees every disease as a psychosomatic manifestation and views the Mind and Body as two aspects of one unit. The three Stambha of Ayurveda are Vata, Pitta and Kapha which control all vital functions of body, to support these Tristambha there are three Upastambha namely Ahara, Nidra and Brahmacharya which increases the strength of Tristambhas. Ayurveda emphasizes mind and body achieves proper relaxation and rest through Nidra. Mainly Vata Vaigunyata is responsible for Anidra. Anidra can be clinically correlated with Insomnia. In modern medical science for the management of Insomnia includes administration of Antipsychotic and Sedatives, each of them is having its own limitations. On the other side, Ayurveda having a light of hope for this condition by correction of basic pathology particularly through Panchakarma, like external treatment in the form of Shirodhara which is one among the Murdhni Taila. In this present study 10 subjects with Primary Insomnia. Treatment given was Shirodhara with Panchasugandha Sadhita Takra Dhara for the duration of 14 days. The treatment had shown positive response by increasing duration of sleep and quality of sleep along with over well being in terms of quality of life.