Reaction of dialkyl-2-aryl-6-hydroxy-6-methyl-4-oxocyclohexane-1,3-dicarboxylates with tosylhydrazide proceeds via the alicyclic carbonyl group to give dialkyl-2-aryl-6-hydroxy-6-methyl-4-(p-toluenesulfonylaminoimino)cyclohexane-1,3-dicarboxylates. The antimicrobial activity of the synthesized compounds has been evaluated.It was established previously that b-cycloketols and their derivatives exhibit antimicrobial and anti-inflammatory activity [1,2]. It seemed interesting to study the reaction of dialkyl 2-aryl-6-hydroxy-6-methyl-4-oxocyclohexane-1,3-dicarboxylates with tosylhydrazine in order to synthesize new biologically active compounds.Diacetyl-substituted cycloketols are known to react with hydrazine to form the corresponding indazoles [3]. The reaction of dialkyl 2-aryl-6-hydroxy-6-methyl-4-oxocyclohexane-1,3-dicarboxylates (Ia -m) with tosylhydrazide with heating in EtOH produced dialkyl 2-aryl-6-hydroxy-6-methyl-4-(p-toluenesulfonylaminoimino)cyclohexane-1,3-dicarboxylates (IIa -m) ( Table 1). R = OCH 3 (Ia, b; IIa, b); OCH(CH 3 ) 2 (Ic, IIc); OC 2 H 5 (Id -i, IId -i);

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