На основе выполненных в работе исследований проведен сравнительный анализ изменения свойств активированных и не активированных смесей и мелкозернистых бетонов на их основе в зависимости от разной удельной поверхности тонкодиспесрных наполнителей: трепела или песка от содержания микронаполнителей: высокоактивного метакаолина, волластонита и водоредуцирующих добавок-суперпластификаторов С-3 или Melflux. Показано, что при переходе на другой вид наполнителя, даже такого же химического состава, оптимальные дозировки всех компонентов и их соотношение необходимо корректировать. При переходе на другой вид приготовления смесей соотношение компонентов также изменяется. Теоретически обоснована и экспериментально подтверждена эффективность совместного использования тонкодисперсных наполнителей заданной дисперсности, суперпластификатора С-3 или Melflux, высокоактивного метакаолина совместно с волластонитом в составе смесей для мелкозернистых бетонов в качестве полифункциональных модификаторов. Проведенные исследования показывают широкие возможности модификации составов органоминеральными экологически безвредными добавками и свидетельствуют о рациональности разработок комплексных полифункциональных модификаторов отдельно для активированных и не активированных мелкозернистых бетонов. Для активированных смесей рационально также нормировать более широкий спектр технологических свойств. Практические результаты, полученные авторами, обеспечивают как повышенные по сравнению с нормированными, так и высокие дополнительные показатели качества. Высокая степень влияния количественного состава мелкозернистых бетонов полифункционального назначения на их свойства предопределяет актуальность разработок универсальных программных комплексов. Разработана информационная модель системы поддержки принятия решений в процессе анализа свойств мелкозернистых бетонов полифункционального назначения.Based on the research performed, a comparative analysis of the changes in the properties of activated and non-activated fine-grained mixtures and solutions depending on the different specific surface fine fillers: finely ground trepel or sand, as well as on the content of inorganic PFM: highly active meta-kaolin, wollastonite and super-plasticizing additive superplasticizer C-3 or Melflux. The carried out researches show wide possibilities of modification of compositions by organomineral ecologically harmless additives and testify to rationality of development of complex additives separately for the activated and not activated fine-grained solutions. It is shown that when switching to another type of filler, even the same chemical composition, the dosages of all components and their ratio should be adjusted optimally. When switching to another type of mixture preparation, the ratio of components. Practical results obtained by the author provide the required and additional quality indicators, increase the physical and mechanical properties of fine-grained solutions, increase productivity. Theoretically substantiated and experimentally confirmed the effectiveness of the joint use of fine fillers, superplasticizer C-3 or Melflux, the high activity of metakaolin and wollastonite as a part of the binder in the fine-grained mixture and concrete. The data model of the decision support system for analyzing the properties of fine-grained multifunctional concrete has been developed.

Introduction. Pathology plays an essential and important role in diagnostic and choosing patients’ management strategies. The aim of our analytical article is to review opportunities of digital technologies applying to pathology with a focus on converges with clinical disciplines. Materials and methods. The search was conducted on Medline and Pubmed database and websites of laboratory equipment developers. Results. The emergence of a new direction – ‘digital pathology’, underlines a high interest of professional society in this theme. Nowadays there are enough solutions for each part of pathological workflow which provides development of fully digitalized pathological laboratories. In this article we present opportunities and perspectives of business-process organization from statements of objectives for pathologist, tissue collection, laboratory study to multidisciplinary analysis for further patients’ management based on opportunities of information technologies. Conclusion. Digital pathology is a transfer of all pathological routine workflow on digital platform which allows to unite efforts of clinicians, pathologists, public health organizers and patients. Separated blocks, which should constitute a united digital pathological platform, already exist and effort and time are required for full consolidation of all stages of pathological research.

Introduction. Nowadays digital pathology is an actively developing area. The basis for changing specialty to digital pathology is a Whole slide imaging method which allows to transfer histological slides into digital form. Significant workload on pathologists and insufficient equipment of pathological states require to change the way pathologists work and to implement new technologies which would allow to optimize and facilitate a work with pathological materials. The aim of this paper is to review solutions for scanning pathomorphological materials available on international and Russian markets and scopes of application of these solutions. Materials and methods. The search was conducted on Pubmed database. The search of information about microscopes-scanners was made on sites of developers including open sources in these sites and FDA site. Results. The application of slide scanning and microscopes for WSI was overviewed, the scopes of application and limitations of digital technologies in medicine were described. Based on literature review a classification of devices used for microslides scanning was made. The first type of devices is microscopes-scanners. They are closed systems for microscopy where cameras and lenses are located inside the device and slides scanning is carried out on high speed with capacity for 400 slides in one load. These microscopes are the most widespread ones nowadays. The second type is microscopes that are similar in shape and size to usual light microscopes. Openness of such system provides using different types of microscopy but the capacity of slides is less than in previous mentioned devices. Nevertheless, these specifications allow to use such microscopes in small laboratories including using in scientific research. Among compact microscopes with the sizes similar to a smartphone some models have a high availability due to printing their parts via 3D printers. But these microscopes are used only for visualization of structures where high magnification isn’t needed. This can limit application of this microscopes type in pathology. The fourth type is an optical microscope with attached details that can transform it to a microscope-scanner. Attached details can be printed via 3D printers and thus their using has a great potential in digital pathology since it significantly reduces the price of the device. In addition, based on this type of microscopes the devices scanning all types of slides can be made and therefore they can be used in all laboratories. Conclusion. Our literature review has shown ample opportunities for application of WSI in pathomorphological microslides scanning. Telepathology is an evolving area of telemedicine which creates a need for developing of new technologies.