No abstract

No abstract

Indomethacin, a non-steroid anti-idammatory drug, was given to 28 patients with acute rheumatic fever or chorea, and its effects compared to 23 similar patients given aspirin. No significant differences were observed either in effects on acute phase manifestations or the incidence of valvular heart disease one year later. Because of the incidence of side efiects in other studies, indomethacin would appear to offer no advantage over aspirin in the therapy of rheumatic fever. NDOMETHACIN,* AN ANTI-INFLAMMATORY agent unrelated to I adrenocortical steroids, has been shown to provide -symptomatic relief in rheumatoid arthritis and other joint diseases.1-5 The present study was designed to compare the effects of indomethacin and aspirin on acute rheumatic fever and its valvular sequelae. MATERIALS AND METHODSTlic study was conducted in the winter of 1962 at the Jose Joaquin Aquirre. Roberto del Rio arid hlanuel Arriarlin hospitals of the University of Chile and the National Health Service, Santiago, Chile. Children and adults hospitalized with suspected acute rheumatic fever were observed and a complete history and physical examination performed. Initial laboratory studies included a sedimentation rate, hematocrit, standard PA chest film for heart size and an electrocardiogram. h serum specimen was taken for antistreptolysin 0 and C-reactive protein determinations. If a patient failed to meet the criteria for admission to the study, the examinations were repeated until a diagnosis was established. All patients diagnosed as having acute rheumatic fever according to the modified criteria of Jones6 were accepted for study. During the observed attack at least one major and two minor criteria or two major criteria must have been present. In addition, on the day therapy was

No abstract

No abstract