No abstract

FAF patterns, baseline area of atrophy, and time of follow-up were associated with GA progression. However, FAF patterns seem to be a consequence (not a cause) of enlarging atrophy and their effect on GA progression seems mostly driven by baseline area of atrophy.

The swine model of a controlled area of circumscribed retinal damage, with well-delimited borders, and selectively of the outer layers of the retina presented herein shows several clinical and histologic features of geographic atrophy in AMD. Therefore, it may represent a valuable tool in the investigation of new emerging regenerative therapies that aim to restore visual function, such as stem cell transplantation or optogenetics.

visual acuity. None of our patients needed more than a short course of steroid drops. Although we do not know which other factors are causing the development of depigmentation of the iris, in none of our patients a concave iris has been the primary factor. Gonioscopy did not reveal pigmentation of the chambre angle. In addition, in pigment glaucoma the pattern of translucency of the iris differs from the pattern seen here, which is similar to the pattern in our patients. In any patient with iris translucency it is wise to evaluate the concavity of the iris by gonioscopy, but it is also possible that in this patient the subconjunctival steroid injection is one of the factors for developing glaucoma.