The purpose of this note is to establish, from the hypergeometric-type difference equation introduced by Nikiforov and Uvarov, new tractable sufficient conditions for the monotonicity with respect to a real parameter of zeros of classical discrete orthogonal polynomials. This result allows one to carry out a systematic study of the monotonicity of zeros of classical orthogonal polynomials on linear, quadratic, q-linear, and q-quadratic grids. In particular, we analyze in a simple and unified way the monotonicity of the zeros of Hahn, Charlier, Krawtchouk, Meixner, Racah, dual Hahn, q-Meixner, quantum q-Krawtchouk, q-Krawtchouk, affine q-Krawtchouk, q-Charlier, Al-Salam–Carlitz, q-Hahn, little q-Jacobi, little q-Laguerre/Wall, q-Bessel, q-Racah, and dual q-Hahn polynomials.

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In this chapter we characterize Askey-Wilson polynomials including specific and limiting cases of them by some structure relations of the first type.