This study was conducted to evaluate Pb and Zn uptake, mobility, and accumulation in Stipa hohenackeriana using field soil in pot and field experiments. Moreover, the effects of Municipal Solid Waste Compost (MSWC) (0, 1, and 2%) and Nano-Silica (NS) (0, 250, and 500 mg/kg) on Stipa biomass, Pb and Zn availability in the soil, and Pb and Zn uptake and accumulation were studied using pot experiments. Samples of soil, root, and shoots of Stipa were collected from field and greenhouse and after drying, extraction of Pb and Zn was done by acid digestion. BioConcentration Factor (BCF) and Translocation Factor (TF) were calculated to determine Pb and Zn phytoremediation efficiency. The amount of Zn and Pb remediation by Stipa from soil was determined by remediation factor (RF). The results of field experiments showed the Pb and Zn level decreased in the order of: soil >shoot>root. Results of the pot experiments also showed that plants grown in NS500-amended pots had 33% and 32% higher Pb in roots and shoots compared to control pots, respectively. In comparison, roots Pb concentration in pots amended with MSWC1% and MSWC2% decreased 22.4% and 1.7%, respectively. Roots and shoots Zn concentration in NS500-amended pots was 5.6% and 6.5% higher, respectively. However, root Zn concentration in treatments of MSWC1% and MSWC2% decreased 52.3% and 39.4%, respectively. Shoots Zn concentration decreased 52.5% and 40.0%, respectively. Although MSWC decreased the uptake and accumulation of Pb and Zn in Stipa roots and shoots, it improved the plant growth and consequently increased RF and soil remediation compared to the NS. Thus, it seems that applying MSWC and NS simultaneously can be a suitable strategy for the purpose of improving phytoremediation capability of Stipa in the Pb and Zn contaminated soils. In general, Stipa can be a suitable candidate for the accumulation of heavy metals, especially for Pb and Zn contaminated soils.