Chalcones (A1-A4) compounds were prepared by reacting an aldehyde (Cinnamaldehyde or terphthaldehyde) with a ketone (4-aminoacetophenone or acetylacetone) in the presence of 30% NaOH as a catalyst and ethanol as a solvent. Derivatives of 1,5-benzodiazepine (A5-A12) were prepared by reacting these prepared chalcones with orthophenylene diamine or 4-methylorthophenylene diamine in a basic medium of sodium hydroxide 10% using the microwave method. Some prepared compounds were used as scavengers of some heavy metals (iron and lead) from heavy water in ecosystems, as the results indicated the ability of these compounds to reduce or withdraw these elements from heavy water. The stability of these compounds was also tested against laser rays, as they showed resistance and stability towards laser rays.